Diabetes & the Heart
Hypertenion
Screening and Diagnosis
Expert Opinion
- Blood pressure should be measured at every routine diabetes visit.
Patients found to have systolic blood pressure >130 mmHg or diastolic blood
pressure >80 mmHg should have blood pressure confirmed on a separate day.
- Orthostatic measurement of blood pressure should be performed to assess
for the presence of autonomic neuropathy.
Treatment
A-Level Evidence
- Patients with diabetes should be treated to a diastolic blood pressure <80
mmHg.
- Patients with a systolic blood pressure of 130 to 139 mmHg or a diastolic
blood pressure of 80 to 89 mmHg should be given lifestyle/behavioral therapy
alone for a maximum of 3 months and then, if targets are not achieved, should
also be treated pharmacologically.
- Patients with hypertension (systolic blood pressure >140 mmHg or diastolic
blood pressure >90 mmHg) should receive drug therapy in addition to
lifestyle/behavioral therapy.
- Initial drug therapy may be with angiotensin-converting enzyme (ACE)
inhibitors, angiotensin receptor blockers (ARBs), beta-blockers, or diuretics.
Additional drugs may be chosen from these classes or another drug class.
- In hypertensive patients with microalbuminuria, an ACE inhibitor or an ARB
should be strongly considered. If one class is not tolerated, the other should
be substituted.
- In patients over age 55 years, with hypertension or without hypertension
but with another cardiovascular risk factor (history of cardiovascular
disease, dyslipidemia, microalbuminuria, smoking), an ACE inhibitor (if not
contraindicated) should be considered to reduce risk of cardiovascular events.
- In patients with a recent myocardial infarction, beta-blockers, in
addition, should be considered to reduce mortality.
B-Level Evidence
- Patients with diabetes should be treated to a systolic blood pressure <130
mmHg.
C-Level Evidence
- In patients with microalbuminuria or overt nephropathy, in whom ACE
inhibitors or ARBs are not well tolerated, a non-dihydropyridine calcium
channel blocker (DCCB) should be considered.
Expert Consensus
- If ACE inhibitors or ARBs are used, monitor renal function and serum
potassium levels.
- In elderly hypertensive patients, blood pressure should be lowered
gradually to avoid complications.
- Patients not achieving target blood pressure on three drugs, including a
diuretic, and patients with severe renal disease should be referred to a
specialist experienced in the care of patients with hypertension.